Wegovy vs Zepbound: Side-by-Side Comparison 2025
Summary: Both are FDA-approved for weight management. Zepbound trials showed higher average weight loss. Wegovy has been available longer. Both have similar weekly injection regimens and GI side effect profiles.
Side-by-Side Comparison
| Category | Wegovy | Zepbound |
|---|---|---|
| Active ingredient | Semaglutide 2.4mg | Tirzepatide 2.5-15mg |
| Manufacturer | Novo Nordisk | Eli Lilly |
| FDA approval | June 2021 | November 2023 |
| Avg weight loss | ~15% body weight | ~20-22% body weight |
| Injection schedule | Weekly auto-injector pen | Weekly auto-injector pen |
| Retail price (uninsured) | ~$1,300-1,500/mo | ~$1,060-1,300/mo |
| Medicare coverage (weight loss) | Not covered | Not covered |
| Compounded available | Yes (semaglutide) | Yes (tirzepatide) |
This comparison is for informational purposes only and does not constitute medical advice. Consult a healthcare provider for personalized guidance.